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回首頁 > 專任教師郭鐘金教授

學術著作

 Publication List: 期刊論文 (since 1992):

  • Huang C-W, Kuo C-C. (2016) A synergistic blocking effect of Mg2+ and spermine on the inward rectifier K+ (Kir2.1) channel pore. Scientific Reports 6:21493
  • Tu .-C, Yang Y-C, Kuo, C.-C. (2016) Modulation of NMDA channel gating by Ca2+ and Cd2+ binding to the external pore mouth. Scientific Reports (in press)
  • Pan M-K, Kuo,S-H, Tai C-H, Liou J-Y, Pei J-C, Chang C-Y, WangY-M, Liu W-C, Wang T-R, Lai W-S, Kuo C-C (2016) Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control. Journal of Clinical Investigation doi:10.1172/JCI88170
  • Huang C-W, Lai, H.-J., Huang, P.-Y., Lee, M.-J., Kuo, C.-C. (2016) The biophysical basis underlying gating changes in the p.V1316A mutant Nav1.7 channel and the molecular pathogenesis of inherited erythromelalgia. PLoS Biology 14(9): e1002561.
  • Tu, Y.-C., Kuo, C.-C. (2015) The differential contribution of GluN1 and GluN2 to the gating operation of the NMDA receptor channel. Pflugers Arch - Eur J Physiology (in press, DOI 10.1007/s00424-014-1630-z)
  • Huang, C-W, Kuo C-C (2015) Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K+ (Kir2.1) channel. <http://www.ncbi.nlm.nih.gov/pubmed/25220134> Pflugers Arch - Eur J Physiology (in press, DOI: 10.1007/s00424-014-1611-2)
  • Pan M-K, Tai C-H, Lin W-C, Pei J-C, Lai W-S, Kuo C-C (2014) Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. Journal of Clinical Investigation 124(10):4629-4641
  • Huang C-W, Kuo C-C (2014) Gating of the Kir2.1 channel at the bundle crossing region by spermine and other intracellular cations. Journal of Cellular Physiology 229(11):1703-21
  • Yang Y-C, Tai C-H, Pan M-K, Kuo C-C (2014) The T-type calcium channel as a new therapeutic target for Parkinson’s disease. Pflugers Arch- Eur J Physiology 466:747-755
  • Huang C-W, Kuo C-C (2014) The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channel. Pflugers Arch - Eur J Physiology 466 (2):275-293
  • Tai C-H, Pan M-K, Lin J-J, Huang C-S, Yang Y-C, Kuo C-C(2012)
    Subthalamic discharges as a causal determinant of parkinsonian motor deficits. Ann Neurol. 72(3):464-76.
  • Yang YC, Lin S, Chang PC, Lin HC, Kuo CC(2011) Functional extension of amino acid triads from the fourthtransmembrane segment (S4) into its external linker in Shaker K+ channels. J. Biol. Chem.
    286:37503-14
  • Tai, C.-H., Tang,Y.-C., Pan, M.-K., Huang, C.-S., Kuo, C.-C. (2011) Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease. Journal of Clinical Investigation (in press)
  • Yang, Y.-C., Huang, C.-S., and Kuo C.-C. (2010) Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels. Anesthesiology 113:160-174
  • Yang YC, Lee CH, Kuo CC. (2010) Ionic flow enhances low-affinity binding: a revised mechanistic view into Mg2+ block of NMDA receptors. J Physiol. 588(Pt 4):633-50
  • Yang YC, Hsieh JK, Kuo, C.-C. (2009)The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na+ channel. Journal of General Physiology 134: 95-113.
  • Chang, H. -R., and Kuo, C.-C. (2008) The activation gate and gating mechanism of the N-methyl-D-aspartate receptor. Journal of Neuroscience 28:1546-1556
  • Chang, H. -R., and Kuo, C.-C. (2008) Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor. Journal of Medicinal Chemistry 51:1534-1545
  • Yang YC, Own CJ, Kuo CC. (2007) A hydrophobic element secures S4 voltage sensor in position in resting Shaker K channels. The Journal of physiology. 582(Pt 3):1059-72.
  • Chang HR, Kuo CC. (2007) Extracellular proton-modulated pore-blocking effects of the anticonvulsant felbamate on NMDA channel. Biophysical journal. 93(6):1981-92.
  • Chang HR, Kuo CC. (2007) Characterization of the Gating Conformational Changes in the Felbamate Binding Site in NMDA Channels. Biophysical journal. 93(2):456-66.
  • Yang, Y. -C., and Kuo, C.-C. (2005) An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+. Journal of General Physiology 125: 465-481.
  • Kuo, C.-C., Chen, W.-Y., and Yang, Y.-C. (2004) Block of tetrodotoxin-resistant Na+ channel pore by multivalent cations: gating modification and Na+ flow dependence. Journal of General Physiology 124: 27-42.
  • Kuo, C.-C., Lin, B.-J., Chang, H.-R., and Hsieh, C.-P.(2004) Use-dependent inhibition of the N-Methy-D-asparate currents by felbamate: a gating modifier with selective binding to the desensitized channels. Molecular Pharmacology 65: 370-380.
  • Yang, Y.-C, and Kuo, C.-C. (2003) The position of the fourth segment of domain 4 determines status of the inactivation fate in Na+ channels. Journal of Neuroscience 23: 4922-4930
  • Kuo, C.-C., Lin, T.-J., and Hsieh, C.-P. (2002) Effect of Na+ flow on cd2+ block of tetrodotoxin-resistant Na+ channels. Journal of General Physiology 120:159-172
  • Yang, Y.-C., and Kuo, C.-C. (2002) Inhibition of Na+ current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker. Molecular Pharmacology 62:1228-1237
  • Kuo, C.-C., and Yang, S. (2001) Recovery from inactivation of T-type Ca2+ channels in rat thalamic neurons. Journal of Neuroscience 21:1884-1892
  • Kuo, C.-C., and Liao, S.-Y. (2000) Facilitation of recovery from inactivation by external Na+ and location of the activation gate in neuronal Na+ channels. Journal of Neuroscience 20:5639-5646
  • Kuo, C.-C., Huang, R.-C., and Lou, B.-S. (2000) Inhibition of Na+ current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels. Molecular Pharmacology 57:135-143
  • Kuo, C.-C., and Chen F.-P. (1999) Zn+ modulation of neuronal transient K+ current: fast and selective binding to the deactivated channels. Biophysical Journal 77:2552-2562
  • Shieh, R.-C., Chang, J.-C., and Kuo, C.-C. (1999) K+ binding sites and interactions between permeating K+ ions at the external pore mouth of an inward rectifier K+ channel (Kir2.1). Journal of Biological Chemistry 274:17424-17430
  • Kuo, C.-C.(1998) Imipramine Inhibition of transient K+ current: an open-channel blocker preventing fast inactivation. Biophysical Journal 12:2845-2857
  • Kuo, C.-C. (1998) A common anticonvulsant binding site for phenytoin, carbamazepine, and lamotrigine in neuronal Na+ channels. Molecular Pharmacology 54:712-721
  • Kuo, C.-C., and Lu, L. (1997) Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurons. British Journal of Pharmacology 121:1231-1238
  • Kuo, C.-C., Chen, R.-S., Lu, L., and Chen, R.-C. (1997) Carbamazepine inhibition of neuronal Na+ currents: quantitative distinction from phenytoin and possible therapeutic implications. Molecular Pharmacology 51:1077-1083
  • Kuo, C.-C. (1997) Deactivation retards recovery from inactivation in Shaker K+ channels. Journal of Neuroscience 17:3436-3444
  • Geula, C., Mesulam, M.-M., Kuo, C.-C., and Tokuno, H. (1995) Postnatal development of cortical acetylcholinesterase-rich neurons in the rat brain: permanent and transient patterns. Experimental Neurology 134:157-178
  • Kuo, C.-C., and Bean, B.P. (1994) Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons. Molecular Pharmacology 46:716-725
  • Kuo, C.-C., and Bean, B.P. (1994) Na+ channels must deactivate to recover from inactivation. Neuron 12:819-829
  • Kuo, C.-C., and Bean, B.P. (1993) G-protein modulation of ion permeation through N-type calcium channels. Nature 365:258-262
  • Kuo, C.-C., and Hess, P. (1993) Block of the L-type Ca2+ channel pore by external and internal Mg2+ in rat phaeochromocytoma cells. Journal of Physiology 466:683-706
  • Kuo, C.-C., and Hess, P. (1993) Characterization of the high-affinity Ca2+ binding sites in the L-type Ca2+ channel pore in rat phaeochromocytoma cells. Journal of Physiology 466:657-682
  • Kuo, C.-C., and Hess, P. (1993) Ion permeation through the L-type Ca2+ channel in rat phaeochromocytoma cells: two sets of ion binding sites in the pore. Journal of Physiology 466:629-655
  • Kuo, C.-C., and Hess, P. (1992) A functional view of the entrances of L-type Ca2+ channels: estimates of the size and surface potential at the pore mouths. Neuron 9:515-526