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學術著作

Publish list:

1. James A. Lin, C.-L., Shyu, and Tzong-Shyuan Lee. 1994. Establishment of Mycoplasma spp. cleaning program in a breeder farm combined with Ofloxacin. Taiwan J. Vet. Med. Ani. Husb. 64: 67-76.
2. James A. Lin, Tzong-Shyuan Lee, J.-S. Wang and K.-T. Tong. 1995. The artifical cryptosporidal infection on immunosuppression of Marek’s disease. Taiwan J. Vet. Med. Anim. Husb. 65: 147-152.
3. James A. Lin and Tzong-Shyuan Lee. 1995. The application of ELISA for detecting antibody to avian influenza virus. J. Chin. Soc. Vet. Sci. 21: 146-151.
4. James A. Lin and Tzong-Shyuan Lee. 1996. Genetic susceptibility to Marek's disease virus of local chickens in Taiwan. Avian Dis. 40: 576-581.
5. James A. Lin and Tzong-Shyuan Lee. 1996. Protectivity of the bivalent Marek's disease vaccines in Taiwan local chickens. J. Chin. Soc. Vet. Sci. 22: 107-112.
6. Li-Ju Wang, Tzong-Shyuan Lee, Fan-Yen Lee, Ru-Chun Pai, and Lee-Young Chau. 1998. Expression of heme oxygenase-1 in atherosclerotic lesions. Am. J. Pathol. 152: 711-720.
7. Fan-Yen Lee, Tzong-Shyuan Lee, Ching-Chien Pan, An-Li Huang, and Lee-Young Chau. 1998. Colocalization of iron and ceroid in human atherosclerotic lesions. Atherosclerosis 138: 281-288.
8. Tzong-Shyuan Lee, Hwei-Chen Yen, Ching-Chien Pan, and Lee-Young Chau. 1999. The role of interleukin 12 in the development of atherosclerosis in apoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 19: 734-742.
9. Tzong-Shyuan Lee, Ming-Shi Shiao, Ching-Chien Pan, and Lee-Young Chau. 1999. Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice. Circulation 99: 1222-1229.
10. Tzong-Shyuan Lee, Fan-Yen Lee, Jong-Hwei S. Pang, and Lee-Young Chau. 1999. Erythrophagocytosis and iron deposition in atherosclerotic lesions. Chin. J. Physiology 41: 17-23.
11. Tzong-Shyuan Lee and Lee-Young Chau. 2001. Fas/Fas ligand mediated death pathway is involved in oxide LDL-induced apoptosis in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 280:C709-C718.
12. Shu-Hui Juan*, Tzong-Shyuan Lee*, Kuang-Wen Tseng, Jun-Yang Liou, Song-Kun Shyue, Kenneth K. Wu, Lee-Young Chau. 2001. Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in ApoE-deficient meic. Circulation 104:1519-1525. (*these authors contributed equally to this work).
13. Tzong-Shyuan Lee and Lee-Young Chau. 2002. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nature Med. 8: 240-246.
14. Tzong-Shyuan Lee, Hui-Ling Tsai and Lee-Young Chau. 2003. Induction of heme oxygenase-1 expression in murine macrophage is essential for the anti-inflammatory effect of low dose 15-deoxy-Δ12,14-prostaglandin J2. J. Biol. Chem. 278: 19325-19330.
15. HT Lee, LL Chiu, Tzong-Shyuan Lee, Hui-Ling Tsai, Lee-Young Chau. 2003. Dietary iron restriction increases plaque stability in apolipoprotein- E-deficient mice. J. Biomed. Sci. 10:510-517.
16. Rui-Hai Zhou, Tzong-Shyuan Lee, Tsui-Chun Tsou, Francois Rannou, Yi-Shuan Li, Shu Chien, John Y.-J Shyy. 2003. Stent Implantation activates Akt in the vessel wall. Role of mechanical stretch in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 23: 2015-2020.
17. Francois Rannou, Tzong-Shyuan Lee, Rui-Hai Zhou, Jennie Chin, Jeffrey C Lotz, Marie-Anne Mayous-Benhamou, Jacques Patrick Barbet, Alain Chevrot, and JY-J. Shyy. 2004. Intervertebral disc degeneration: The role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. Am. J. Pathol. 164: 915-924.
18. Yi Liu, Yi Zhu, Francois Rannou, Tzong-Shyuan Lee, Kitty Formentin, Lingfang Zeng, Xiaohui Yuan, Nanping Wang, Shu Chien, Barry M. Forman, and John Y-J. Shyy. 2004. Laminar flow activates peroxisome proliferator-activator receptor. Circulation 110: 1128-1133.
19. Rui-Hai Zhou, Yao Min, Tzong-Shyuan Lee, Yi Zhu, Martins-Green Manuela, John Y-J. Shyy. 2004. Vascular endothelial growth factor activation of sterol regulatory element binding protein. A potential role in angiogenesis. Circ Res. 95:471-478.
20. Tzong-Shyuan Lee, Chih-Chieh Chang, Yi Zhu, and John Y-J. Shyy. 2004. Simvastatin induction of heme oxygenase-1: A novel mechanism of vessel protection. Circulation 110: 1296-1302.
21. Lingfang Zeng, Hailing Liao, Yi Liu , Tzong-Shyuan Lee, Minjia Zhu, Xian Wang, Michael B Stemerman, Yi Zhu, John Y-J Shyy. 2004. SREBP2 downregulates ABCA1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem. 279:48801-48807.
22. Yi Zhu, Hailing Liao, Xuefen Xie, Yuan Yuan, Tzong-Shyuan Lee, Nanping Wang, Xian Wang, John Y.-J. Shyy and Michael B. Stemerman. 2005. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc Res. 68: 425-432.
23. Yi Liu , Yingjia Zhang , Kara Schmelzer, Tzong-Shyuan Lee, Xiang Fang , Yi Zhu, Arthur A. Spector, Sarjeet Gill, Christophe Morisseau, Bruce D. Hammock and John Y.-J. Shyy. 2005. The anti-inflammatory effect of laminar flow: The role of PPAR
γ, EETs and sEH. Proc Natl Acad Sci U S A. 102:16747-16752.
24. Yingjia Zhang, Tzong-Shyuan Lee, Erik M. Kolb; Kai Sun, Xiao Lu, Frances M. Sladek; Ghassan S. Kassab; Theodore Garland, Jr; John Y.-J. Shyy. 2006. AMP-Activated Protein Kinase Is Involved in Endothelial NO Synthase Activation in Response to Shear Stress. Arterioscler Thromb Vasc Biol. 26:1281-1287.
25. Wei Sun*, Tzong-Shyuan Lee*, Minjia Zhu, Yi Zhu, John YJ Shyy. 2006. Statins activate AMP-activated kinase in vitro and in vivo. Circulation. 114: 2655-2662. (*these authors contributed equally to this work).
26. You-Lan Yang, Gau-Jun Tang, Yuh-Lin Wu, Huey-Wen Yien, Tzong-Shyuan Lee*, Yu Ru Kou*. 2008. Exacerbation of wood smoke-induced acute lung injury by mechanical ventilation using moderately high tidal volume in mice. Respiratory Physiology & Neurobiology. 160:99-108. (*Corresponding author)
27. Yuh-Lin Wu, Hsiang-Hao Chuang, Ru Yu Kou, Tzong-Shyuan Lee, Shing-Hwa Lu, Yu-Chu Huang, Yoshihiro Nishi, Toshihiko Yanase. 2008. Regulation of LH Receptor and PGF2
α Receptor Signaling by the Regulator of G Protein Signaling 2 (RGS2) in Human and Mouse Granulosa Cells. Chinese Journal of Physiology. 51: 1-10.
28. Tzong-Shyuan Lee, Yu-Ju Liu, Huey-Wen Yien, Yuh-Lin Wu, Yu Ru Kou. 2008. Wood smoke extract promotes both apoptosis and proliferation in rat alveolar epithelial type II cells: the role of oxidative stress and heme oxygenase-1. Crit Care Med. 36:2597-2606.
29. Ya-Shan Cheng, Tzong-Shyuan Lee, Hui-Chi Hsu, Yu Ru Kou, Yuh-Lin Wu. 2008. Characterization of the transcriptional regulation of the regulator of G protein signaling 2 (RGS2) gene during 3T3-L1 preadipocyte differentiation. J Cell Biochem. 105:922-930.
30. Tzong-Shyuan Lee, Chun-Yueh Lin, Jin-Yi Tsai, Yuh-Lin Wu, Kuo-Hui Su, Kuo-Yun Lu, Sheng-Huang Hsiao, Ching-Chian Pan, Yu Ru Kou, Yung-Pei Hsu, Low-Tone Ho. 2009. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci. 84: 97-104.
31. Kuo-Hui Su, Jin-Yi Tsai, Yu Ru Kou, An-Na Chiang, Sheng-Huang Hsiao, Yuh-Lin Wu, Hsin-Han Hou, Ching-Chian Pan, Song-Kun Shyue, Tzong-Shyuan Lee*. 2009. Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling. Cardiovasc Res. 82:468-475. (*Corresponding author)
32. Chiu-Ling Hsu, Yuh-Lin Wu, Gau-Jun Tang, Tzong-Shyuan Lee*, Yu Ru Kou*. 2009. Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: Role of heme oxygenase-1. Pulm Pharmacol Ther. 22:286-296. (*Corresponding author)
33. Tsai CY, Tzong-Shyuan Lee, Yu Ru Kou, Yuh-Lin Wu. 2009. Glucosamine inhibits IL-1
β-mediated IL-8 production in prostate cancer cells by MAPK attenuation. J Cell Biochem. 108: 489-498.
34. Po-Ling Yu, Ching-I Wu, Tzong-Shyuan Lee, Wynn H.T. Pan, Paulus S. Wang, and Shyi-Wu Wang. 2009. Estradiol attenuated the reduction of striatal dopamine by amphetamine in ovariectomized rats. J Cell Biochem. 108: 1318-1324.
35. Yu Ru Kou, Tzong-Shyuan Lee. 2010. Intratracheal siRNA for the in vivo silencing of caspase-3: A novel therapy for acute lung injury? Crit Care Med. 38:1223-1224. (Editorial)
36. Kuo-Yun Lu, Li-Chieh Ching, Kuo-Hui Su, Yuan-Bin Yu, Yu Ru Kou, Sheng-Huang Hsiao, Yu-Chu Huang, Chien-Yu Chen, Li-Ching Cheng, Ching-Chian Pan, Tzong-Shyuan Lee*. 2010. Erythropoietin suppresses the formation of macrophage foam cells: Role of liver X receptor
 α.Circulation. 121: 1828-1837. (*Corresponding author)
37. Yuh-Lin Wu, Yu Ru Kou, Hui-Ling Ou, Han-Yun Chien, Kun-Han Chuang, Han-Hsun Liu, Tzong-Shyuan Lee, Cheng-Yen Tsai, Meng-Lun Lu. 2010. Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 635: 219-226.
38. Tzong-Shyuan Lee*, Ching-Chian Pan, Chien-Chung Peng, Yu Ru Kou, Chien-Yu Chen, Li-Chieh Ching, Tsung-Huang Tsai, Ping-Chiang Lyu, Shu-Fen Chen, and Song-Kun Shyue*. 2010. Anti-atherogenic effect of berberine on LXRα-ABCA1-dependent cholesterol efflux in macrophages. J Cell Biochem. 111: 104-110. (*Corresponding author)
39. Jin-Yi Tsai, Kuo-Hui Su, Song-Kun Shyue, Yu Ru Kou, Yuan-Bin Yu, Sheng-Huang Hsiao, An-Na Chiang, Yuh-Lin Wu, LC Ching, Tzong-Shyuan Lee*. 2010. EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: Role of heme oxygenase-1. Cardiovasc Res. 88: 415-423. (*Corresponding author)
40. Tsung-Huang Tsai, Shu-Fen Chen, Tai-Yu Huang, Chun-Fu Tzeng, Ann-Shyn Chiang,Yu Ru Kou, Tzong-Shyuan Lee*, and Song-Kun Shyue*. 2011. Impaired CD14 and CD36 expression, bacterial clearance and toll-like receptor 4–MyD88 signaling in caveolin-1–deleted macrophages and mice. Shock. 35: 92-99. (*Corresponding author)
41. Tzu-Ming Wang, Chun-Jung Chen, Tzong-Shyuan Lee, Han-Yi Chao, Wen-Huey Wu, Shu-Chen Hsieh, Huey-Herng Sheu and An-Na Chianga. 2011. Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells. J Nutr Biochem. 22:187-194.
42. Wen-Chin Chiu, Chun-Jung Chen, Tzong-Shyuan Lee, Zit-Jie, Chen, Pei-Hsin Ke, and An-Na Chiang. 2011. Oxidative stress enhances AP-1 and NF-κB-mediated regulation of β2-glycoprotein I gene expression in hepatoma cells. J Cell Biochem. 111: 988-998.
43. Li-Ching Cheng, Kuo-Hui Su, Li-Chieh Ching, Song-Kun Shyue, Yu Ru Kou, Yuh-Lin Wu, Kuo-Yun Lu, Chien-Yu Chen, Ching-Chian Pan, Tzong-Shyuan Lee*.2011. α-lipoic acid ameliorates foam cell formation via liver X receptor α-dependent up-regulation of ATP-binding cassette transporter A1 and G1. Free Radic. Biol. Med. 50: 47-54. (*Corresponding author)
44. Che-Feng Chang, Shu-Fen Chen, Tzong-Shyuan Lee, Hung-Fu Lee, Szu-Fu Chen, Song-Kun Shyue. 2011. Caveolin-1 Deletion Reduces Early Brain Injury after Experimental Intracerebral Hemorrhage. Am. J. Pathol. 178: 1749-1761.
45. Chun-Yueh Lin*, Tzong-Shyuan Lee*, Chin-Chang Chen, Cheng-An Chang, Yan-Jie Lin, Yung-Pei Hsu, Low-Tone Ho. 2011. Endothelin-1 exacerbates lipid accumulation by increasing the protein degradation of the ATP-binding cassette transporter G1 in macrophages. J Cell Physiol: 226: 2198-2205. (*these authors contributed equally to this work).
46. Kuo-Hui Su, Song-Kun Shyue, Li-Chieh Ching, Yu Ru Kou, An-Na Chiang, Yuan-Bin Yu, Chien-Yu Chen, Ching-Chian Pan, Tzong-Shyuan Lee*. 2011. β common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase. J Cell Physiol. 226:3330-3339. (*Corresponding author)
47. Gau-Jun Tang, Hsin-Yi Wang, Jen-Ying Wang, Chih-Chieh Lee, Hsu-Wen Tseng, Yuh-Lin Wu, Song-Kun Shyue, Tzong-Shyuan Lee*, Yu Ru Kou*. 2011. The novel role of the AMP-activated protein kinase signaling in the induction of IL-8 in human lung epithelial cells and lung inflammation in mice by cigarette smoke. Free Radic. Biol. Med. 50:1492-502.
48. Li-Chieh Ching, Yu Ru Kou, Song-Kun Shyue, Kuo-Hui Su, Jeng Wei, Li-Ching Cheng, Yuan-Bin Yu, Ching-Chian Pan, Tzong-Shyuan Lee*. 2011. Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by endothelial transient receptor potential vanilloid type 1. Cardiovasc Res. 91:492-501. (*Corresponding author)
49. Chi-Huei Chiang, Chiao-Hui Chuang, Shiou-Ling Liu, Tzong-Shyuan Lee, Yu Ru Kou, Haibo Zhang. 2011. Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Intensive Care Med. 37:1360-1367.
50. Tzong-Shyuan Lee, Yu Ru Kou. 2011. How alcohol impairs the granulocyte expansion during septicemia. Crit Care Med. 39: 2194-2195.
51. Chien-Yu Chen, Li-Chieh Ching, Song-Kun Shyue, An-Na Chiang, Yuh-Lin Wu, Yu Ru Kou, Ching-Chian Pan, Tzong-Shyuan Lee*. 2011. Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation on ATP-binding cassette transporter-A1 in macrophage foam cells. J Nutr Biochem. 22:1015-1021. (*Corresponding author)
52. Yu-Wen Hung, Sing-I Yang, Pei-Yu Huang, Tzong-Shyuan Lee, Terry B.J. Kuo, Chun-Hing Yiu, Yang-Hsin Shih, Yung-Yang Lin. 2012. The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats. Epilepsy Research. 98:206-215.
53. Yi-Jen Liao, Tzu-Lang Chen, Tzong-Shyuan Lee, Hsiang-An Wang, Chung-Kwe Wang, Li-Ying Liao, Ren-Shyan Liu, Shiu-Feng Huang, and Yi-Ming Arthur Chen. 2012. Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. Molecular Medicine. 18:412-422.
54. Hsin-Han Hou, Bruce D. Hammock, Kou-Hui Su, Yu Ru Kou, Christophe Morisseau, Susumu Imaoka, Ami Oguro, Song-Kun Shyue, Jin-Feng Zhao, and Tzong-Shyuan Lee*. 2012. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase. Cardiovasc Res. 93:120-129. (*Corresponding author)
55. Tzong-Shyuan Lee, Yu Ru Kou. 2012. Enhancing endothelial progenitor cell therapy for critical limb ischemia by extracorporeal shock wave. Crit Care Med. 40:332-333.
56. Kuo-Hui Su, Yuan-Bin Yu, Hsin-Han Hou, Jin-Feng Zhao, Yu Ru Kou, Li-Ching Cheng, Song-Kun Shyue, Tzong-Shyuan Lee*. 2012. AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase. J Cell Physiol. 27: 3053-3062. (*Corresponding author)
57. Jing-Feng Zhao, Li-Chieh Ching, Yu-Chu Huang, Chien-Yu Chen, An-Na Chiang, Yu Ru Kou, Song-Kun Shyue, Tzong-Shyuan Lee*. 2012. Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis. Mol Nutr Food Res. 56:691-701. (*Corresponding author)
58. Hung-Fu Lee, Tzong-Shyuan Lee*, Yu Ru Kou*. 2012. Anti-inflammatory and neuroprotective effects of triptolide on traumatic brain injury in rats. Respiratory Physiology & Neurobiology. 182: 1-8. (*Corresponding author).
59. Yuan-Bin Yu, Yu-Wen Liao, Kou-Hui Su, Tsung-Ming Chang, Song-Kun Shyue, Yu Ru Kou*, Tzong-Shyuan Lee*. 2012. Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke. Acta Physiologica (Oxford). 205: 532-540. (*Corresponding author)
60. Chien-Yu Chen, Li-Chieh Ching, Yi-Jen Liao, Yuan-Bin Yu, Chia-Yuan Tsou, Song-Kun Shyue, Yi-Ming Arthur Chen*, Tzong-Shyuan Lee*. 2012. Deficiency of glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice. Molecular Medicine. 18: 744-752. (*Corresponding author)
61. Yu-Cheng Chang, Tzong-Shyuan Lee, An-Na Chiang. 2012. Quercetin enhances ATP-binding cassette transporter A1 expression and cholesterol efflux through a p38-dependent pathway in macrophages. J Lipid Res. 53: 1840-1850.
62. Yu YB, Gau JP, Liu CY, Yang MH, Chiang SC, Hsu HC, Hong YC, Hsiao LT, Liu JH, Chiou TJ, Chen PM, Tzong-Shyuan Lee, Chou LF, Tzeng CH, Chen TJ. 2012. A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system. Thromb Haemost. 108: 225-235.
63. Li-Chieh Ching, Chien-Yu Chen, Kuo-Hui Su, Hsin-Han Hou, Song-Kun Shyue, Yu Ru Kou, Tzong-Shyuan Lee*. 2012. Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase. Molecular Medicine. 18: 805-815. (*Corresponding author)
64. Ko-Lin Kuo, Szu-Chun Hung, Yao-Ping Lin, Ching-Fang Tang, Tzong-Shyuan Lee, Chih-Pei Lin, Der-Cherng Tarng. 2012. Intravenous ferric chloride hexahydrate supplementation induced endothelial dysfunction and increased cardiovascular risk among hemodialysis patients PLos One. 7: e50295.
65. Wen-Chin Chiu, Jan-Yu Lin, Tzong-Shyuan Lee, Li-Ru You, An-Na Chiang. 2013. β-Glycoprotein I inhibits VEGF-induced proliferation and migration of human aortic endothelial cells and suppresses phosphorylation of VEGFR2, ERK1/2 and Akt. Mol Cell Biochem. 372: 9-15.
66. Diahn-Warng Perng, Tsung-Ming Chang, Jen-Ying Wang, Chih-Chieh Lee, Shing-Hwa Lu, Song-Kun Shyue, Tzong-Shyuan Lee*, Yu Ru Kou*. 2013. Inflammatory role of AMP-activated protein kinase signaling in experimental model of wood-smoke inhalation injury. Crit Care Med. 41: 120-132. (*Corresponding author)
67. Jeng Wei, Li-Chieh Ching, Jin-Feng Zhao, Song-Kun Shyue, Yu Ru Kou, Tzong-Shyuan Lee*. 2013. Essential role of transient receptor potential vanilloid type 1 in the evodiamine-mediated protection against atherosclerosis in apolipoprotein E deficient mice. Acta Physiologica (Oxford). 207:299-307. (*Corresponding author)
68. Jin-Feng Zhao, Li-Chieh Ching, Yu Ru Kou, Shing-Jong Lin, Jeng Wei, Song-Kun Shyue*, Tzong-Shyuan Lee*. 2013. Activation of TRPV1 prevents oxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages: Role of liver X receptor. Mediators of Inflammation. 925171. (*Corresponding author)
69. Jin-Feng Zhao, Shr-Jeng Jim Leu, Song-Kun Shyue, Kuo-Hui Su, Jeng Weid*, Tzong-Shyuan Lee*. 2013. Novel effect of paeonol on the formation of foam cells: Promotion of LXRα-ABCA1-dependent cholesterol efflux in macrophages. Am J Chin Med. 41:1079-1096. (*Corresponding author)
70. Li-Chieh Ching, Jin-Feng Zhao, Kuo-Hui Su, Song-Kun Shyue, Chiao-Po Hsu, Tse-Min Lu, Shing-Jong Lin, Tzong-Shyuan Lee*. 2013. Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C. Acta Physiologica (Oxford). 209:124-135. (*Corresponding author)
71. Wei-Wen Chen, Chen-Hao Chien, Chiung-Lin Wang, Huai-Hsien Wang, Yuh-Lin Wang, Shih-Torng Ding, Tzong-Shyuan Lee, Ta-Chau Chang. 2013. Automated quantitative analysis of lipid accumulation and hydrolysis in living macrophages with label-free imaging. Anal Bioanal Chem. 405:8549-8559.
72. Jin-Feng Zhao, Song-Kun Shyue, Shing-Jong Lin, Jeng Wei*, Tzong-Shyuan Lee*. 2014. Excess nitric oxide impairs liver X receptor α-ATP-binding cassette transporter A1-dependent cholesterol efflux in macrophage foam cells. J Cell Physiol. 229:117-125. (*Corresponding author)
73. Hsin-Kuo Ko, Wen-Hu Hsu, Chin-Cheng Hsieh, Te-Cheng Lien, Tzong-Shyuan Lee, Yu Ru Kou. 2014. High expression of high-mobility group box 1 in the blood and lungs is associated with the development of chronic obstructive pulmonary disease in smokers. Respirology 19:253-261.
74. Wen-Yueh Chou, Jin-Feng Zhao, Yi-Ming Arthur Chen, Kuan-I Lee, Kuo-Hui Su, Song-Kun Shyue, Tzong-Shuan Lee*. 2014. Role of glycine N-methyltransferase in experimental ulcerative colitis. J Gastroenterol Hepatol. 29:494-501. (*Corresponding author)
75. Chia-Yuan Tsou, Chien-Yu Chen, Jin-Feng Zhao, Kuo-Hui Su, Hsueh-Te Lee, Shing-Jong Lin, Song-Kun Shyue, Sheng-Huang Hsiao*, Tzong-Shyuan Lee*. 2014. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiologica. 210: 799-810. (*Corresponding author)
76. Yuh-Lin Wu, An-Hsuan Lin, Chao-Hung Chen, Wen-Chien, Huang, Hsin-Yi Wang, Meng-Han Liu, Tzong-Shyuan Lee*, Yu Ru Kou*. 2014. Glucosamine attenuates cigarette smoke induced-lung inflammation via its antioxidant function and inhibition of ROS-sensitive inflammatory signaling. Free Radic. Biol. Med. 69: 208-218. (*Corresponding author)
77. Kuo-Hui Su, Kuan-I Lee, Song-Kun Shyue, Jeng Wei, Tzong-Shyuan Lee*. 2014. Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. Int J Biol Sci. 10: 990-996. (*Corresponding author)
78. Meng-Han Liu, An-Hsuan Lin, Hung-Fu Lee, Hsin-Kuo Ko, Tzong-Shyuan Lee*, Yu Ru Kou*. 2014. Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Mediators of Inflammation. 2014:651890 (*Corresponding author)
79. Kuo-Hui Su, Shing-Jong Lin, Jeng Wei, Sheng-Huang Hsiao, Kuan-I Lee, Jin-Feng Zhao, Song-Kun Shyue*, Tzong-Shyuan Lee*. 2014. The essential role of transient receptor potential vanilloid 1 in simvastatin-induced activation of endothelial nitric oxide synthase and angiogenesis. Acta Physiologica. 212: 191–204. (*Corresponding author)
80. Ko-Lin Kuo, Szu-Chun Hung, Tzong-Shyuan Lee*, Der-Cherng Tarng*. 2014. Iron sucrose accelerates early atherogenesis through increasing superoxide production and up-regulation of adhesion molecules in mice of remnant kidney. Journal of the American Society of Nephrology 25:2596-606. (*Corresponding author)
81. Meng-Han Liu, An-Hsuan Lin, Shing-Hwa Lu, Ruo-Yun Peng, Tzong-Shyuan Lee*, Yu Ru Kou*. 2014. Eicosapentaenoic acid attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Frontiers in Physiology: Respiratory Physiology. 5: 440.
82. Yu-Wen Hung, Shao-Wen Hung, Yi-Chen Wu, Lin-King Wong, Ming-Tsong Lai, Yang-Hsin Shih, Tzong-Shyuan Lee*, Yung-Yang Lin*. 2015. Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. Brain, Behavior, and Immunity. 43: 118-129. (*Corresponding author)
83. Kuan-Chuan Pao, Jin-Feng Zhao, Tzong-Shyuan Lee, Ying-Pei Huang, Chien-Chung Han, Lin-Chiang Sherlock Huang, Ming-Hua Hsu*. 2015. Low-dose paeonol derivatives alleviate lipid accumulation. RSC Advances 5:5652-5656.
84. Hsin-Kuo Ko, Hung-Fu Lee, An-Hsuan Lin, Meng-Han Liu, Ching-I Liu, Tzong-Shyuan Lee*, Yu Ru Kou*. 2015. Regulation of cigarette smoke induction of IL-8 in macrophages by AMP-activated protein kinase signaling: Role of nAChRs and ROS. J Cell Physiol. 230: 1781-1793.(*Corresponding author)
85. Chin-Wei Chiang, Hsueh-Te Lee, Der-Cherng Tarng, Ko-Lin Kuo, Li-Ching Cheng, Tzong-Shyuan Lee*. 2015. Deletion of soluble epoxide hydrolase attenuates inflammation and fibrosis in experimental obstructive nephropathy. Mediators of Inflammation. 2015:693260. (*Corresponding author)
86. Bei-Chia Guo, Jeng Wei, Kuo-Hui Su, An-Na Chiang, Li-Ching Cheng, Jin-Feng Zhao, Song-Kun Shyue, Tzong-Shyuan Lee*. 2015. Transient receptor potential vanilloid type 1 is vital in (-)-epigallocatechin-3-gallate-mediated activation of endothelial nitric oxide synthase. Mol Nutr Food Res. 59: 646-657. (*Corresponding author)
87. Tzong-Shyuan Lee*, Kuo-Yun Lu, Yuan-Bin Yu, Hsueh-Te Lee, Feng-Chuan Tsai. 2015. β common receptor mediates erythropoietin-conferred suppression on oxLDL-induced lipid accumulation and inflammation in macrophages. Mediators of Inflammation. 2015:439759. (*Corresponding author)
88. Hsin-Han Hou, Yi-Jen Liao, Sheng-Huang Hsiao, Song-Kun Shyue, Tzong-Shyuan Lee*. 2015. Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase. Scientific Reports 5:13524. (*Corresponding author).
89. An-Hsuan Lin, Meng-Han Liu, Hsin-Kuo Ko, Diahn-Warng Perng, Tzong-Shyuan Lee* and Yu Ru Kou*. 2015. Lung epithelial TRPA1 transduce the extracellular ROS into transcriptional regulation of lung inflammation induced by cigarette smoke: the role of influxed Ca2+. Mediators of Inflammation. 2015:148367. (*Corresponding author)
90. Han-Fang Wu, Hsin-Ju Yen, Chi-Chen Huang, Yi-Chao Lee, Su-Zhen Wu, Tzong-Shyuan Lee, Hui-Ching Lin. 2015. Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex. J Biomed Sci. 22:94.
91. Jin-Feng Zhao, Song-Kun Shyue, Tzong-Shyuan Lee*. 2016. Excess nitric oxide activates TRPV1-Ca2+-calpain signaling and promotes the PEST-dependent degradation of liver X receptor  α. Int J Biol Sci. 12:18-29. (*Corresponding author)
92. Jin-Feng Zhao, Sheng-Huang Hsiao, Ming-Hua Hsu, Kuan-Chuan Pao, Yu Ru Kou, Song-Kun Shyue, Tzong-Shyuan Lee*. 2016. Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice. Archives of Toxicology. 90: 181-190. (*Corresponding author)
93. Kuan-I Lee, Chin-Wei Chiang, Hui-Ching Lin, Jin-Feng Zhao, Cheng-Ta Li, Song-Kun Shyue, Tzong-Shyuan Lee*. 2016. Maternal di-(2-ethylhexyl) phthalate exposure deregulates blood pressure, adiposity, cholesterol metabolism and social interaction in offspring. Archives of Toxicology. 90:1211-1224. (*Corresponding author)
94. Chiao-Po Hsu, Jin-Feng Zhao, Shing-Jong Lin, Song-Kun Shyue, Bei-Chia Guo, Tse-Min Lu*, Tzong-Shyuan Lee*. 2016. Asymmetric dimethylarginine limits the efficacy of simvastatin activating endothelial nitric oxide synthase. J Am Heart Assoc. 5: e003327. (*Corresponding author)
95. Kuan-I Lee, Hsueh-Te Lee, Hui-Ching Lin, Huey-Jen Tsay, Feng-Chuan Tsai, Song-Kun Shyue, Tzong-Shyuan Lee*. 2016. Transient receptor potential ankyrin 1 channels in Alzheimer’s disease. Journal of Neuroinflammation. 13:92. (*Corresponding author)
96. Jin-Feng Zhao, Song-Kun Shyue, Yu Ru Kou, Tse-Min Lu*, Tzong-Shyuan Lee*. Transient receptor potential ankyrin 1 channel involved in atherosclerosis and macrophage-foam cell formation. 2016. Int J Biol Sci. 12: 812-823. (*Corresponding author)
97. Wei-Ming Chen, Wayne H-H Sheu, Pei-Chi Tseng, Tzong-Shyuan Lee, Wen-Jane Lee, Pey-Jium Chang, Chiang. 2016. Modulation of microRNA expression in subjects with metabolic syndrome and decrease of cholesterol efflux from macrophages via microRNA-33-mediated attenuation of ATP-binding cassette transporter A1 expression by statins. PLOS ONE. 11: e0154672.
98. Yuh-Ching Twu, Tzong-Shyuan Lee, Yun-Lian Lin, Shih-Ming Hsu, Yuan-Hsi Wang, Chia-Yu Liao, Chung-Kwe Wang, Yu-Chih Liang, Yi-Jen Liao. 2016. Niemann-Pick type C2 protein mediates hepatic stellate cells activation by regulating free cholesterol accumulation. Int J Mol Sci. 17: 1122.
99. Yi-Jen Liao, Tzong-Shyuan Lee, Yuh-Ching Twu, Ching-Ping Yang, Chung-Kwe Wang, Shih-Ming Hsu, Yu-Chih Liang, and Yi-Ming Chen. 2016. Glycine N-methyltransferase deficiency accumulate triglycerides and impair insulin signaling by modulating PI3K/Akt pathway in the liver. J Biomed Sci. 23:69.
100. Tse-Min Lu, Chiao-Po Hsu, Chao-Fu Chang, Chih-Ching Lin, Tzong-Shyuan Lee, Shing-Jong Lin, Wan-Leong Chan. Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization. Atherosclerosis. 254:161-166.
101. Yuan-Bin Yu, Kuo-Hui Su, Bei-Chia Guo, Kuan-I Lee, Jeng Wei, Tzong-Shyuan Lee*. 2016. Transient receptor potential vanilloid 1 in regulating erythropoietin-induced activation of endothelial nitric oxide synthase. Acta Physiologica. 219:465-477.
102. Kuan-I Lee, Hui-Ching Lin, Hsueh-Te Lee, Feng-Chuan Tsai, Tzong-Shyuan Lee*. 2017. Loss function of transient receptor potential ankyrin 1 channels deregulates emotional, social, cognitive, learning and memory development. Molecular Neurobiology. 54:3606-3617. (*Corresponding author)
103. Meng-Han Liu, An-Hsuan Lin, Hsin-Kuo Ko, Diahn-Warng Perng, Tzong-Shyuan Lee*, Yu Ru Kou*. 2017. Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol. Frontiers in Physiology: Respiratory Physiology. 8:193. (*Corresponding author)
104. An-Hsuan Lin, Meng-Han Liu, Hsin-Kuo Ko, Diahn-Warng Perng, Tzong-Shyuan Lee*, Yu Ru Kou1*. 2017. Inflammatory effects of menthol versus non-menthol cigarette smoke extract on human lung epithelial cells: a double-hit on TRPM8 by ROS and menthol. Frontiers in Physiology: Respiratory Physiology. 27;8:263. (*Corresponding author)

105. Tse-Min Lu, Tzong-Shyuan Lee, Shing-Jong Lin, Wan-Leong Chan, Chiao-Po Hsu. 2017. The prognostic value of asymmetric dimethylarginine in patients with cardiac syndrome X. PLoS One. 12:e0188995.
106. Hsueh-Te Lee, Kuan-I Lee, Hui-Ching Lin, Tzong-Shyuan Lee*. 2018. Genetic deletion of soluble epoxide hydroxylase causes anxiety-like behaviors in mice. Molecular Neurobiology. In Press. (*Corresponding author)
107. Chia-Hui Chen, Song-Kun Shyue, Chia-Po Hsu, Tzong-Shyuan Lee*. 2018. Atypical antipsychotic drug olanzapine deregulates hepatic lipid metabolism and aortic inflammation and aggravates atherosclerosis. Cell Physiol Biochem. In Press. (*Corresponding author)
108. Jin-Feng Zhao, Hsiang-Ying Chen, Jeng Wei, Shr-Jeng Jim Leu, Tzong-Shyuan Lee*. 2018. CCN family member 1 deregulates cholesterol metabolism and aggravates atherosclerosis. Acta Physiologica (Oxford). In Press. (*Corresponding author)