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Che-Feng Chang, PhD
Assistant Professor,
Graduate Institute of Physiology,
National Taiwan University College of Medicine
Taipei, Taiwan

 

TEL: 886-2-23123456 ext.88243
FAX: 886-2-23964350
E-mail: chefengchang@ntu.edu.tw

 

Dr. Chang's research is driven by the desire to develop effective medical therapy for intracerebral hemorrhage (ICH). He seeks to better understand the interaction between immune cells and/or CNS cells in the context of diseases. The Chang lab establishes and uses innovative neuroimmunological and computational tools to study the characteristics and reaction of specific immune cell population in the injured brain. They have also established in vivo, in vitro, and ex vivo platforms to mimic different types of ICH injury.

Even better than treating disease itself is to prevent disease from occurring in the first place. Dr. Chang’s intent, therefore, is to understand how environmental factors and dietary habits influence innate immune cells for cerebrovascular disease prevention.

Dr. Chang is committed to training the next generation of biomedical scientists including MS, PhD, MD-PhD, and postdoctoral trainees. He believes in and practice providing a stimulating and collaborative environment that promotes the free exchange of ideas and encourages creative scientificthinking.

 

ACADEMIC EXPERIENCE

2018.08-
Assistant Professor, Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan

2017.08-2018.07
Associate Research Scientist/Junior Research Faculty, Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA

2015.04-2017.07
Postdoctoral Fellow, Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA

2013.01-2015.04
Postdoctoral Fellow, Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA


HONORS AND AWARDS

2019 Outstanding alumni award, Graduate Institute of Physiology, National Defense Medical Center, Taipei, Taiwan

2017 Travel grant, the 6th World Intracranial Hemorrhage Conference, Baltimore, MD, USA

2015 Postdoctoral fellowship, Ministry of Science and Technology, Taiwan

2013 1st Place award, the 15th Annual ACCM Research Day, Johns Hopkins University, School of Medicine, Baltimore, MD, USA

2012 Excellent soldier award, Army General Headquarters, Republic of China Army, Taiwan

2011 Award of excellent Ph.D. thesis sponsored by Dr. Chien-Tien Hsu, the 19th Symposium on Recent Advances in Cellular and Molecular Biology, Kaohsiung, Taiwan

2011 Young investigators travel grant, the 13th International TNF Conference, Awaji, Japan

2011 Outstanding students conference travel grant, Foundation for the Advancement of Outstanding Scholarship, Taipei, Taiwan

2011 Ph.D. student thesis research award, the 11th Student Thesis Workshop of the Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

2010 Honorable Mentions, the 10th Student Thesis Workshop of the Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan


PUBLICATIONS (*corresponding author)

Chang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, Landreneau MJ, Ai Y, Beatty H, Costa L, Mack M, Sheth KN, Greer DM, Huttner A, Coman D, Hyder F, Ghosh S, Rothlin CV, Love JC, Sansing LH*. Efferocytosis of erythrocytes modulates macrophages towards recovery after intracerebral hemorrhage. Journal of Clinical Investigation. 2018; 128: 607-624.

Taylor RA, Chang CF, Goods BA, Hammond MD, Grory BM, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, and Sansing LH*. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. Journal of Clinical Investigation. 2017; 127: 280–292.

Chang CF, Wan J, Li Q, Renfroe SC, Heller NM*, and Wang J. Alternative activation-skewed microglia/macrophages promote hematoma resolution after intracerebral hemorrhage. Neurobiology of Disease. 2017; 103: 54-69.

Wang M, Hong X, Chang CF (equal contribution first-author), Li Q, Ma B, Zhang H, Xiang S, Heo HY, Zhang Y, Lee DH, Jiang S, Leigh R, Koehler RC, van Zijl PC, Wang J*, and Zhou J*. Simultaneous detection and separation of hyperacute intracerebral hemorrhage and cerebral ischemia using amide proton transfer MRI. Magnetic Resonance in Medicine. 2015; 74: 42-50.

Zhao X, Wu T*, Chang CF (equal contribution first-author), Wu H, Han X, Li Q, Gao Y, Li Q, Hou Z, Maruyama T, Zhang J, Wang J*. Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain, Behavior, and Immunity. 2015; 46: 293–310.

Chang CF, Cai L, Wang J*. Translational intracerebral hemorrhage: a need for transparent descriptions of fresh tissue sampling and preclinical model quality. Translational Stroke Research. 2015; 6:384-389.

Chang CF, Suzy C, Wang J*. (-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways. Annals of Clinical and Translational Neurology. 2014; 4:258-271.

Zhu W, Gao Y, Chang CF, Wan JR, Zhu SS, Wang J*. Mouse models of intracerebral hemorrhage in ventricle, cortex, and hippocampus by injections of autologous blood or collagenase. PLoS One. 2014; 9(5):e97423.

Chang CF, Chen SF, Lee TS, Lee HF, Chen SF*, Shyue SK*. Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage. American Journal of Pathology. 2011; 178:1749-1761.